Santos Samuel Fonseca, 21, and Jonathan Salazar, 20, crawled through a 22in (55cm) hole they cut in a toilet ceiling at the jail in the city of Salinas, south of San Francisco.
The local sheriff's office said the men had exploited a "blind spot".
The two were awaiting trial for separate murder charges when they escaped on Sunday.
"We're disappointed that there are people charged with homicide who are no longer in our jail," Jonathan Thornburg, a spokesman for the Monterey County Sheriff's Office, said.
Authorities are searching for the fugitives, who are considered armed and dangerous.
The sheriff's office is offering a $5,000 (£3,800) reward for information about the suspects' whereabouts.
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